The Wolf Foundation said Tuesday that Domingo is the first vocal artist to ever win its prize. From 1962 to 1965, at the beginning of his career, he sang with the Israeli opera company.
Each year the Wolf Foundation awards $100,000 prizes in five fields. About three dozen winners have gone on to receive Nobel Prizes.
Domingo shared the award with English conductor Sir Simon Rattle. Israeli physicist Jacob D. Bekenstein won the physics prize.