Russia said Friday it intercepted two Ukrainian missiles over its southern Rostov region bordering Ukraine, with at least 16 people wounded by debris falling on the city of Taganrog.

Regions bordering Ukraine have seen regular drone strikes and shelling since Moscow launched its military campaign in February last year, but have hardly ever been targeted by missiles.

"Russian air defence equipment detected the Ukrainian missile and intercepted it in the air. The debris of the downed Ukrainian missile fell on the territory of Taganrog," a defence ministry statement said.

The ministry said the first S-200 missile was aimed at "residential infrastructure" of Taganrog, a city of around 250,000 people.

Shortly after, it said it downed a second S-200 missile near the city of Azov, with debris falling in an unpopulated area.

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Rostov region governor Vasily Golubev said 15 people suffered "light injuries" from shards in an explosion near the "Chekhov Garden" cafe in central Taganrog.

"Rescuers are at the scene. There are no dead. There are several injured to whom ambulances have been dispatched," Golubev said on Telegram.

Emergency services told Russian news agencies TASS and Ria Novosti that 16 people were injured, 10 of whom were hospitalised, with one in serious condition.

Golubev said that the "epicentre of the explosion" was in the Taganrog Art Museum, a few hundred metres from the cafe.

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He said a museum wall, its roof and outbuildings were destroyed. The window frames of a nearby three-storey apartment block were damaged by the impact.

Taganrog is located on the coast of the Sea of Azov and about 40 kilometres (25 miles) from the border with Ukraine.

The city is also on a road leading to the port city of Mariupol, which was captured by Russian forces last year following a devastating siege.

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